METHYL METHANESULPHONATE

Name	Methyl methanesulfonate
Synonyms	MMS CB 1540 as-dimethylsulfite as-dimethylsulphite as-Dimethyl sulphite Methyl methanesulfonate METHYL METHANESULFONATE METHYLMETHANE SULPHONATE METHYL METHANESULPHONATE Methanesulfonic acid methyl ester METHANESULFONIC ACID METHYL ESTER
CAS	66-27-3
EINECS	200-625-0
InChI	InChI=1/C2H6O3S/c1-5-6(2,3)4/h1-2H3
InChIKey	MBABOKRGFJTBAE-UHFFFAOYSA-N

Molecular Formula	C2H6O3S
Molar Mass	110.13
Density	1.3g/mLat 25°C(lit.)
Melting Point	20°C
Boling Point	202-203°C(lit.)
Flash Point	220°F
Water Solubility	200 g/L (20 ºC)
Solubility	200g/l
Vapor Presure	0.8 hPa (59 °C)
Appearance	Liquid
Color	Colorless to pale yellow
Merck	14,6097
BRN	1098586
Storage Condition	Store below +30°C.
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases.
Refractive Index	n20/D 1.414(lit.)

Hazard Symbols	T - Toxic
Risk Codes	R45 - May cause cancer R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R68 - Possible risk of irreversible effects
Safety Description	S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	UN 2810 6.1/PG 3
WGK Germany	3
RTECS	PB2625000
FLUKA BRAND F CODES	21
TSCA	Yes
HS Code	2905 19 00
Hazard Class	6.1(b)
Packing Group	III
Toxicity	LD50 orally in Rabbit: 225 mg/kg

(IARC) carcinogen classification	2A (Vol. 7, Sup 7, 71) 1999
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
genotoxicity	mesylate is a genotoxic impurity with a limit of 1.5g/d. 1 The daily dose is 800 mg, accordingly, the limit of MMS and EMS must not be more than 1.875G/G. Preclinical studies of some mesylate esters have found that these mesylate esters can directly react with biological macromolecules (DNAs,RNAs and proteins) by alkylation, which may lead to DNA mutation, carcinogenic effect and teratogenic effect.
varieties of sulfonic acid esters	methanesulfonic acid, benzene methane sulfonic acid and other sulfonate substances and trace amounts of lower alcohols in the synthesis reaction to generate alkyl sulfonate, such as methyl Methane Sulfonate (MMS), Ethyl Methane Sulfonate (EMS), isopropyl Methane Sulfonate (IMS), N-butyl methanesulfonate (NBMS), as well as aryl sulfonates such as methyl benzenesulfonate (MBS), ethyl benzenesulfonate (EBS), p-toluenesulfonate (MP-TS), which can alkylate with DNA, thus, it may become a cause of cancer, so it is very important to control the threshold of toxicological concern (TTC) level of such impurities in drugs, the European EMA has published a maximum intake of genotoxic impurities of 1.5 μg/d.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 21:04:16

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